Abcam, ab115040, Anti-HSPC142 antibody

Size: 100µg
Rabbit Polyclonal HSPC142 antibody. Suitable for IP and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human BABAM1 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human BABAM1 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q9NWV8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HSPC142 also called CCDC53 is a protein involved mechanically in several cellular processes. It weighs approximately 38 kDa and is expressed broadly in many tissues. HSPC142 plays a significant role in the regulation of cytoskeletal dynamics suggesting it is important in maintaining cellular integrity. Researchers often study HSPC142 to understand its localization and interactions within different cellular compartments.
Biological function summary
HSPC142 contributes to the organization and function of the actin cytoskeleton. It forms part of the WASH (Wiskott-Aldrich syndrome protein and SCAR homolog) complex which is important for actin nucleation. This complex works with other proteins to facilitate processes like endosomal sorting and membrane trafficking. It aids in maintaining proper cellular function by influencing actin filament assembly and disassembly.
Pathways
Researchers recognize HSPC142’s role in the regulation of the Arp2/3 complex pathway and the WASH pathway. Here HSPC142 interacts with proteins such as WASH1 and F-actin driving changes in the cytoskeleton necessary for cellular transport activities. These interactions ensure that cells can move materials efficiently indicating a broader impact on cellular homeostasis and signaling processes.
Studies link HSPC142 to neurodegenerative conditions and cancers. Disruptions in its function can lead to abnormal cell migration and changes in the brain's cellular architecture. In Alzheimer's disease models alterations in cytoskeletal dynamics due to faulty HSPC142 pathways show significant connections with tau proteins. In cancer unregulated HSPC142 activity associates with increased cell invasion and metastasis implicating other proteins like WAVE2 in these transformative processes.