Abcam, ab11570, Anti-Chondroitin Sulfate antibody [CS-56]

Size: 50µL
Anti-Chondroitin Sulfate antibody [CS-56] (ab11570) is a mouse monoclonal antibody detecting Chondroitin Sulfate in IHC-P, ICC/IF, EM . - Over 70 publications - Trusted since 2004
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:CS-56,
Isotype:IgM,
Carrier free:No,
Applications:ICC/IF, EM, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:The antibody has been reported to be specific for the glycosaminoglycan (GAG) portion of native chondroitin sulfate proteoglycan (CSPG). The antibody reacts specifically with chondroitin sulfate types A and C but not with type B (dermatan sulfate), and may be used for localization of chondroitin sulfate in tissues and cultured fibroblasts.

Product details:
What is this antibody validated in?
Anti-Chondroitin Sulfate antibody [CS-56] (ab11570) is a mouse monoclonal antibody and is validated for use in Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF), Electron microscopy (EM).
Trusted by the scientific community
Anti-Chondroitin Sulfate [CS-56] (ab11570) was first used in a scientific publication in 2004 and has been cited over 70 times in peer-reviewed journals.
Reviewed by scientists
Anti-Chondroitin Sulfate [CS-56] (ab11570) has over 5 independent reviews from customers.

Properties and Storage Information:
Form-Liquid, Purification technique-Proprietary technique, Purification notes-Purified from Tissue culture supernatant., Storage buffer-pH: 7.4Preservative: 0.097% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Chondroitin sulfate also known as CS-56 or chondroitin sulphate is a complex carbohydrate considered part of the glycosaminoglycan family. This molecule plays a mechanical role in the extracellular matrix providing structural integrity and resistance to compression in tissues such as cartilage. The mass of chondroitin sulfate can vary due to its polymeric nature typically ranging from 30 to 50 kDa. It is expressed mainly in the cartilage but you can also find it in bone skin and connective tissues. It contributes to the physical properties of these tissues enabling them to withstand force and stress.
Biological function summary
Chondroitin sulfate participates in cellular processes like cell growth and differentiation by interacting with cell surface receptors. It is a component of proteoglycans forming complex structures with proteins that help maintain the viscoelastic properties of tissues. These proteoglycan complexes play various roles by modulating the behavior of surrounding cells and influencing tissue repair and regeneration. In cartilage chondroitin sulfate contributes to the formation of the strong yet flexible matrices that help in joint movement and load-bearing.
Pathways
Chondroitin sulfate participates in the extracellular matrix organization and signal transduction pathways. It interacts with proteins such as aggrecan and versican which are essential components of the cartilage homeostasis pathways. The presence of chondroitin sulfate in these pathways allows it to modulate interactions between matrix components and cellular signaling. This biological function supports proper tissue construction and maintenance necessary for normal physiological conditions and quick recovery from tissue injuries.
Chondroitin sulfate is linked to osteoarthritis and connective tissue disorders. Osteoarthritis characterized by cartilage degradation involves the breakdown of chondroitin sulfate and related proteoglycans such as aggrecan. Restoration of chondroitin sulfate levels has been shown to help in maintaining cartilage integrity and reducing inflammation. In connective tissue disorders alterations in chondroitin sulfate structure or expression can lead to compromised tissue resilience and elasticity. Understanding the interaction between chondroitin sulfate and proteins involved in these conditions is critical for developing therapeutic strategies.