Abcam, ab115785, Anti-DDT antibody

Size: 100µg
Rabbit Polyclonal DDT antibody. Suitable for IHC-P, WB and reacts with Human, Rat, Mouse samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human DDT.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human DDT. The exact immunogen used to generate this antibody is proprietary information.P30046

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate)Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DDT also referred to as D-dopachrome tautomerase is an important protein involved in several biological processes. It has a molecular mass of approximately 12 kDa. The protein is widely expressed in multiple tissues particularly in the liver and macrophages which are integral to immune response and metabolism. Analyzing DDT expression through Western blot techniques can provide insights into its concentration and functional state in various tissues.
Biological function summary
D-dopachrome tautomerase plays roles in melanin biosynthesis and inflammatory processes. It forms part of a complex with the macrophage migration inhibitory factor (MIF) influencing immune response regulation. DDT shares structural and functional similarities with MIF suggesting evolutionary links between these proteins and indicating possible redundant or cooperative roles in immune system modulation.
Pathways
DDT is involved in the immune response pathway and the melanin synthesis pathway. Within the immune response its interactions have connections with cytokine regulation and leukocyte movement. DDT's interaction with MIF further highlights its involvement in modulating cytokine activity. In melanin synthesis DDT contributes to the conversion processes within the pathway although proteins like tyrosinase also play significant roles.
Links exist between DDT and inflammatory diseases like rheumatoid arthritis and skin disorders like melanoma. Higher DDT levels can coincide with increased inflammation seen in rheumatoid arthritis where it potentially works alongside MIF to modulate immune activity. In melanoma DDT's role in melanin synthesis may connect it to abnormal pigment cell growth and tumor progression. Understanding DDT's interactions with other proteins in these contexts could lead to better diagnostic or therapeutic strategies.