Abcam, ab116406, Recombinant Human TRF1 protein

Size: 10µg
Recombinant Human TRF1 protein is a Human Full Length protein, in the 1 to 419 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, ELISA, WB, Mass Spec.
Key facts
Purity:>90% SDS-PAGE,
Expression system:Escherichia coli,
Tags:6x His tag N-Terminus GST tag N-Terminus,
Applications:WB, ELISA, SDS-PAGE, Mass SpecSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P54274,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7.4Constituents: 99% PBS

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TRF1 also known as TERF1 (Telomeric Repeat Binding Factor 1) is an important protein involved in telomere maintenance. This protein has a molecular mass of approximately 55 kDa. TRF1 localizes specifically to telomeres and plays an essential role in shelterin complex formation a specialized protein complex that protects chromosome ends. TRF1 is highly expressed in proliferating cells and tissues especially those with a high rate of cell division.
Biological function summary
TRF1 contributes to the stabilization of telomere structure and regulates telomere length. TRF1 is a part of the shelterin complex which also includes proteins such as TRF2 POT1 TIN2 RAP1 and TPP1. The shelterin complex prevents the telomeres from being recognized as DNA damage and regulates their replicative processes. TRF1 interacts directly with telomeric DNA influencing replication and modulating access to telomerase the enzyme responsible for telomere elongation.
Pathways
TRF1 plays a significant role in telomere maintenance and the cell cycle. The protein is critical in the DNA damage response pathway where it prevents unwanted DNA repair activities at telomeres. In this context TRF1 interacts with proteins like ATM and ATR which are important for signaling and responding to DNA damage. TRF1's interaction with these pathways helps maintain genomic stability and cellular homeostasis.
Alterations in TRF1 function can contribute to cancer and aging-related diseases. High levels or overexpression of TRF1 are frequently observed in certain cancers where it may help tumor cells maintain telomeres and proliferate indefinitely. Conversely lower TRF1 levels are associated with premature aging disorders such as dyskeratosis congenita. In these conditions the connection between TRF1 and TRF2 within the shelterin complex plays an important role in maintaining telomere integrity affecting disease development and progression.