Abcam, ab117063, Recombinant Human ADAM2 protein

Size: 10µg
Recombinant Human ADAM2 protein is a Human Full Length protein, in the 1 to 716 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
Key facts
Expression system:Wheat germ,
Tags:GST tag N-Terminus,
Applications:ELISA, WB, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q99965,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.3% Glutathione

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ADAM2 also known as fertilin beta is a member of the ADAM (a disintegrin and metalloprotease) family. It is a protein with a mass of approximately 100 kDa. ADAM2 contains a disintegrin and metalloproteinase domain which are responsible for its adhesive and protease activities. Expression of ADAM2 occurs mainly in the testis especially in mature spermatozoa where it plays essential roles in reproduction processes.
Biological function summary
The ADAM2 protein functions in sperm-egg interactions facilitating sperm binding to the egg's surface during fertilization. It is part of a multi-protein complex that also includes ADAM1 which enhances the binding efficiency to the egg zona pellucida. ADAM2's disintegrin domain is thought to interact with integrins on the egg membrane while the metalloproteinase domain might process surrounding proteins to prepare for fertilization.
Pathways
ADAM2 actively participates in reproduction-related signaling pathways particularly the integrin-mediated cell adhesion pathway. It collaborates with other ADAM family proteins and integrins to ensure successful fertilization. Another important pathway is the gamete fusion pathway where ADAM2 assists in the fusion process alongside other proteins such as ADAM3 ensuring gamete membrane fusion and subsequent fertilization.
Abnormalities in ADAM2 expression or function can lead to male infertility making this protein a biomarker of reproductive health concerns. It has a known association with other ADAM proteins such as ADAM3 which also plays a role in sperm maturation and fertility. Researchers are interested in how alterations in ADAM2 and these related proteins contribute to infertility offering potential insights for therapeutic interventions.