Abcam, ab117122, Anti-HIV gp160 antibody

Size: 100µg
Goat Polyclonal ENV antibody. Suitable for ELISA, WB and reacts with Human immunodeficiency virus samples. Cited in 1 publication.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human immunodeficiency virus,
Applications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:ab117122 reacts strongly with gp41, gp120 and gp160 in western blot assays. ELISA based peptide mapping studies have confirmed high titer reactivity to HIV MN env peptide in the following regions: (6332)IEPLGVAPTKAKRRV, (6360) CTTTVPWNASWSNKS and moderate activity to multiple other regions on the env polypeptide.

Properties and Storage Information:
Form-Liquid, Purification technique-Ion exchange chromatography, Storage buffer-Preservative: 0.09% Sodium azideConstituents: 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle, Store undiluted

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HIV gp160 also known as Env glycoprotein gp160 weighs approximately 160 kDa. This glycoprotein is expressed on the surface of HIV-infected cells. It plays an important role in the virus's lifecycle by facilitating entry into host cells. gp160 undergoes cleavage into two subunits gp120 and gp41 which remain non-covalently linked. This precursor glycoprotein is essential for the formation of HIV's envelope structure and is a major determinant of infectivity.
Biological function summary
Env glycoprotein gp160 mediates HIV-1’s entry into host cells. This protein forms a complex with CD4 and co-receptors usually CCR5 or CXCR4 on the surface of target cells. The binding of gp120 to CD4 and the co-receptors triggers necessary conformational changes for the fusion of the viral and cellular membranes. This fusion step is critical for the viral RNA to enter the host cell setting the stage for replication and propagation of the virus.
Pathways
Env glycoprotein gp160 is integral to the HIV entry pathway. The gp160 cleavage products gp120 and gp41 participate in membrane fusion events essential for viral entry. gp120 interacts with CD4 and co-receptors particularly involved in recruiting host cell machinery to facilitate infection. These interactions also link to the endocytic pathways that transport viral contents into the host cell.
Gp160 links directly to HIV/AIDS pathogenesis. As an important player in virus entry mutations in gp160 can influence the virus's ability to infect host cells and may lead to immune escape with implications in resistance. Furthermore gp160's interaction with CD4 and its ability to trigger immune response also relate to the depletion of T helper cells characteristic of HIV infection. Understanding the interaction between gp160 and these immune system components provides insight into potential therapeutic strategies.