Abcam, ab117456, Anti-HIGD1A antibody

Size: 100µg
Rabbit Polyclonal HIGD1A antibody. Suitable for ICC, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human HIGD1A.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, ICC, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human HIGD1A. The exact immunogen used to generate this antibody is proprietary information.Q9Y241,
Specificity:ab117456 is predicted to not cross-react with HIG2.

Product details:
Avoid repeated freeze thaw cycles and exposure to prolonged high temperatures.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab117456 was purified by affinity chromatography via a peptide column., Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HIGD1A also known as Hypoxia Inducible Gene Domain Family Member 1A functions as a mitochondrial protein. It weighs approximately 12 kDa. It localizes within the inner mitochondrial membrane where it regulates respiratory chain activity. HIGD1A expresses in multiple tissues with high levels in the brain heart and skeletal muscle. It plays a role in cellular responses to hypoxic stress conditions modulating mitochondrial energy production.
Biological function summary
The protein influences cellular survival during low oxygen levels which makes it essential in the physiological adaptation to hypoxia. HIGD1A integrates into the larger mitochondrial complex IV also known as cytochrome c oxidase. By interacting closely with this complex HIGD1A adjusts mitochondrial output and efficiency thereby impacting the generation of reactive oxygen species and ATP in the cell. This association highlights the protein's role in maintaining metabolic balance.
Pathways
HIGD1A participates importantly in the hypoxia signaling pathway and the oxidative phosphorylation pathway. In the hypoxic condition it stabilizes hypoxia-inducible factors (HIFs) that play a central role in adapting cellular metabolism. Furthermore HIGD1A works alongside other proteins like NDUFA4 and COX4I1 key components of the electron transport chain. These connections highlight HIGD1A’s role in energy metabolism and stress response pathways.
The protein establishes a relationship with ischemic conditions and neurodegenerative diseases. It shows altered expression in ischemic cardiac and brain tissues suggesting a protective response to hypoxic injury. Specifically changes in HIGD1A expression levels connect to disorders like Alzheimer's disease. In these conditions the interaction with proteins such as APOE may influence disease progression through mechanisms related to cellular energy metabolism and stress response.