Abcam, ab117756, Anti-ZBTB2 antibody

Size: 100µL
Rabbit Polyclonal ZBTB2 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ZBTB2 aa 450 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ZBTB2 aa 450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8N680

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab117756 was affinity purified using an epitope specific to ZBTB2 immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: 99% Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZBTB2 also known as Zinc finger and BTB domain-containing protein 2 is a transcriptional regulator with a molecular mass of approximately 95 kDa. It operates by binding DNA through its zinc finger motifs and recruiting chromatin remodeling complexes via the BTB/POZ domain affecting gene expression. You can find this protein expressed in various tissues with higher presence notably in the testis brain and some tumor tissues. As a result its expression pattern suggests a significant role in cellular proliferation and differentiation.
Biological function summary
ZBTB2 influences gene transcription and modulates cell cycle progression. It does not work alone but often forms part of transcriptional complexes. Its role in repressing or activating transcription depends on its interaction partners impacting key cellular processes. The protein’s ability to regulate numerous downstream effectors underlines its importance in maintaining cellular homeostasis and normal cellular function.
Pathways
Studies show ZBTB2 involvement in the p53 signaling and Wnt pathways which are important for regulating cell cycle and apoptosis. ZBTB2 interacts with E2F1 a regulator of cell cycle progression and negatively influences p53 activity reducing its transcriptional response. This interaction links ZBTB2 to cell growth and survival pathways making it a focus for understanding complex regulatory networks within cells.
Researchers find ZBTB2 correlated with cancer and neurodevelopmental disorders. Aberrant expression of ZBTB2 has been observed in various malignancies such as colorectal and gastric cancers where it modulates oncogenic pathways. It shows interaction with the MYC proto-oncogene protein enhancing transcriptional programs associated with cell proliferation and tumor development. In neurodevelopmental contexts altered ZBTB2 function can affect neural gene expression contributing to disorders like autism spectrum disorders.