Abcam, ab117761, Anti-TBLR1/TBL1XR1 antibody [4F3-A8-D9]

Size: 100µL
Mouse Monoclonal TBLR1/TBL1XR1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, African green monkey, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TBL1XR1.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:4F3-A8-D9,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human, African green monkey, Mouse,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TBL1XR1. The exact immunogen used to generate this antibody is proprietary information.Q9BZK7

Product details:
This product was changed from ascites to tissue culture supernatant on 17.08.2018. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Purification technique-Cross-flow filtration, Storage buffer-pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TBLR1 also known as TBL1XR1 is a protein that plays an important role in transcription regulation mechanisms. This protein with a molecular mass of approximately 64 kDa is expressed in various tissues including the brain and lungs. It functions as an adaptor protein facilitating interactions between different transcription factors and the corepressor complex. By doing so it enables the repression or activation of specific genes according to cellular needs.
Biological function summary
TBLR1 participates in the regulation of gene expression by being part of the SMRT/N-CoR repressor complex. This complex interacts with nuclear receptors to modulate gene transcription. Through this function TBLR1 contributes to processes involved in maintaining cellular homeostasis. Its role in this complex marks it as a contributor to the fine-tuning of cellular responses to external stimuli which is essential for normal cellular function.
Pathways
The regulation of transcription by TBLR1 integrates into significant signaling pathways like Wnt and nuclear receptor pathways. It partners with proteins such as beta-catenin in the Wnt signaling pathway and corepressors in the nuclear receptor pathway. Through these partnerships TBLR1 affects important developmental and metabolic processes linking transcriptional machinery to broader regulatory networks in the cell.
TBLR1 has associations with conditions such as cancer and autism spectrum disorder. Mutations or dysregulation in the TBLR1 gene can affect normal cellular signaling leading to aberrant cell growth in cancers or disrupted neural development in autism. Additionally it is connected to the action of the protein N-CoR which is also implicated in these diseases. Through these associations TBLR1 becomes a target of interest for understanding and potentially treating these disorders.