Abcam, ab117771, Anti-ZNF462 antibody

Size: 100µg
Rabbit Polyclonal ZNF462 antibody. Suitable for IHC-P, IP, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ZNF462 aa 2450 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ZNF462 aa 2450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q96JM2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab117771 was affinity purified using an epitope specific to ZNF462 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF462 also known as Zinc Finger Protein 462 is a protein with a mass of approximately 280 kDa. It acts as a transcription factor due to its zinc finger domains which allows it to bind to specific DNA sequences and regulate gene expression. This target is widely expressed in the brain heart and skeletal muscle. It plays a part in the developmental processes by influencing the expression of various genes.
Biological function summary
ZNF462 influences the regulation of neural crest development and craniofacial morphogenesis. This protein often functions alongside other transcription factors and may form part of a larger transcriptional complex. Its role is essential in modulating the activity of genes responsible for developmental patterning and cell differentiation.
Pathways
This protein plays a part in the Wnt signaling pathway and the TGF-beta signaling pathway. These pathways are key in developmental processes and cellular communication. ZNF462 interacts with proteins like beta-catenin and SMADs which are central mediators within these pathways managing signals that dictate cell fate determination and tissue homeostasis.
ZNF462 mutations connect to disorders like Weiss-Kruszka syndrome and some craniofacial abnormalities. This protein's dysfunction influences genes related to developmental genes often in conjunction with other transcription factors such as ZIC2 and GLI3. These interactions can disrupt normal craniofacial development leading to syndromic features and developmental delays observed in related disorders.