Abcam, ab117819, Anti-ATL3 antibody

Size: 100µL
Rabbit Polyclonal ATL3 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human Atlastin-3 aa 350-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human Atlastin-3 aa 350-400. The exact immunogen used to generate this antibody is proprietary information.Q6DD88

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: 99% Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The ATL3 protein also known as Atlastin GTPase 3 functions mechanically in cellular processes like membrane fusion. It belongs to the family of dynamin-like GTPases characterized by their ability to hydrolyze GTP to fuel various cellular activities. ATL3 has a molecular mass of about 61 kDa. Expression of ATL3 occurs in various tissues with a significant presence in the brain possibly hinting at its specific roles in neurological functions.
Biological function summary
ATL3 participates in the maintenance of the tubular network of the endoplasmic reticulum (ER). The protein often acts as a dimer and works similarly to other members of the atlastin family. This dimerization and its involvement in membrane fusion aid in creating and maintaining the three-dimensional structure of the ER which is important for various cellular functions and signaling pathways. ATL3 also contributes to the proper spatial arrangement of organelles inside the cells.
Pathways
ATL3 is actively involved in the endoplasmic reticulum morphogenesis pathways. The protein plays an important role in shaping the ER which impacts lipid metabolism and protein synthesis pathways. It closely interacts with other ER-shaping proteins such as ATL1 and ATL2 assisting in retaining the three-dimensional integrity of the ER network that is essential for efficient cellular functioning and response to stress.
Mutations or malfunctions in ATL3 can be associated with hereditary sensory and autonomic neuropathy type I. This relation highlights the significance of ATL3 in neuronal health potentially because of its influence on the ER's structure that affects neuron survival. Additionally there is a connection between ATL3 dysfunction and hereditary spastic paraplegia with ATL1 as another implicated protein indicating a broader impact on neurodegenerative conditions. Understanding ATL3's role not only clarifies its function but also offers insight into potential therapeutic targets for related diseases.