Abcam, ab118603, Anti-PGC1 beta antibody

Size: 100µg
Goat Polyclonal PGC1 beta antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PPARGC1B aa 1-50.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PPARGC1B aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q86YN6

Product details:
This product may be covered by one or more of the following U.S. Patents.
6,166,192
6,426,411
6,525,178
6,872,391
6,908,987
7,250,283
7,091,006
7,354,738
8,105,774
8,445,233

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 99% Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PGC1 beta also known as PPARGC1B or PERC is an important transcriptional coactivator involved in the regulation of genes related to energy metabolism. It has a molecular weight of approximately 102 kDa. Researchers have found PGC1 beta expressed in various tissues with high metabolic activity including heart skeletal muscle liver and brown adipose tissue. By interacting with numerous nuclear receptors and other transcription factors PGC1 beta modulates the transcription of genes important for mitochondrial biogenesis and function.
Biological function summary
PGC1 beta plays a significant role in the regulation of energy homeostasis and adaptive thermogenesis. It partners with specific DNA-binding proteins as part of large coactivator complexes to enhance transcriptional activity. Essential to maintaining energy balance PGC1 beta facilitates the switch between glucose and fatty acid oxidation in response to metabolic demands. This coactivator's ability to interact with key metabolic regulators such as PPARs and ERRα highlights its vital role in cellular energy regulation.
Pathways
PGC1 beta has an important role in energy metabolism including the oxidative phosphorylation and fatty acid oxidation pathways. It functions closely with PPAR-γ and PPAR-α as well as other proteins like NRF1 and NRF2 to regulate the expression of genes involved in mitochondrial function. PGC1 beta activates these pathways contributing to efficient energy utilization and mitochondrial biogenesis important for adapting to varying energy requirements.
PGC1 beta has associations with metabolic diseases like type 2 diabetes and obesity. Altered expression or function of PGC1 beta can disrupt normal metabolic regulation leading to energy imbalance and insulin resistance. Studies link PGC1 beta modulation to liver disease as well connecting it with proteins such as SIRT1 which also plays a role in metabolic homeostasis and cellular stress responses. Understanding PGC1 beta's involvement in these diseases could provide insights into potential therapeutic approaches for metabolic disorders.