Abcam, ab118790, Anti-DOCK7 antibody

Size: 100µg
Rabbit Polyclonal DOCK7 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human DOCK7 aa 150-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human DOCK7 aa 150-250. The exact immunogen used to generate this antibody is proprietary information.Q96N67

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab118790 was affinity purified using an epitope specific to DOCK7 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DOCK7 a member of the Dedicator of Cytokinesis (DOCK) family is a guanine nucleotide exchange factor (GEF) that specifically activates Rac1 and Rac3 GTPases. The DOCK7 protein has a molecular mass of approximately 240 kDa. It is widely expressed in various tissues with significant levels found in the brain contributing to its critical functions in neuronal development.
Biological function summary
The protein plays an important role in neurogenesis and neuronal polarization. DOCK7 is not part of a complex itself but it interacts with other proteins to execute its functions. This protein influences neuronal morphology and axon formation by regulating cytoskeletal dynamics. Through these actions DOCK7 affects the movement and differentiation of neurons during development.
Pathways
The protein participates significantly in the Rac signaling pathway which is important for actin cytoskeleton reorganization. This involvement consequently impacts cellular processes like migration and cell shape regulation. DOCK7 directly relates to the functions of the Rac1 and Rac3 proteins. These proteins partake in pathways that guide axon guidance and neuronal migration emphasizing DOCK7’s role in neurodevelopment.
Dysfunctions involving the protein have associations with neurological conditions like epilepsy and learning disabilities. Mutations or dysregulation in DOCK7 can impact the function of Rac1 disrupting normal neuronal function and leading to disease phenotypes. Understanding these connections may offer insights into therapeutic targets for neurological disorders where these pathways are disrupted.