Abcam, ab118797, Anti-CEP128 antibody

Size: 100µg
Rabbit Polyclonal CEP128 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human CEP128 aa 1000 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CEP128 aa 1000 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q6ZU80

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CEP128 also known as centrosomal protein 128 kDa plays a mechanical role in cell division. It has a molecular mass of approximately 128 kDa and localizes in the centrosome of cells. CEP128 shows expression in various tissues especially those with high cellular proliferation rates. Its primary function involves regulating microtubule organization during cell division processes. CEP128 facilitates centrosome anchoring and ultimately contributes to accurate chromosomal segregation.
Biological function summary
CEP128 interacts with other proteins as part of the centrosomal complex. It assists in maintaining centrosome cohesion and stability. This ability to manage centrosome integrity ensures proper duplication and segregation during mitosis. The centrosomal complex including CEP128 protects cells from errors in chromosome distribution reducing genomic instability.
Pathways
CEP128 integrates into critical cellular signaling processes. It participates in the cell cycle control and mitotic spindle assembly pathways. CEP128 connects with proteins such as PLK4 and CEP152 which are essential for centriole duplication and spindle assembly checkpoint regulation. These biological pathways emphasize CEP128's role in ensuring orderly cell cycle progression.
CEP128 shows relevance to certain cancers and developmental disorders. Its perturbation can result in centrosome-related abnormalities notably contributing to breast cancer formation due to chromosomal instability. Additionally its association with genes like BRCA1 links CEP128 to genetic pathways tied to cancer susceptibility. Disorders involving improper microtubule dynamics or chromosome mis-segregation often correlate with altered CEP128 expression or function.