Abcam, ab119773, Anti-PRIC4/PRICKLE4 antibody

Size: 100µg
Rabbit Polyclonal PRIC4/PRICKLE4 antibody. Suitable for ICC, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PRICKLE4.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PRICKLE4. The exact immunogen used to generate this antibody is proprietary information.Q2TBC4,
Specificity:Two isoforms of PRICKLE4 are known to exist. PRICKLE4 antibody is predicted to not cross-react with other PRICKLE protein family members.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: 99% Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PRIC4 also known as PRICKLE4 is a protein involved in cellular processes like planar cell polarity. It weighs about 130 kDa and expresses itself in several tissues including the central nervous system and the kidney. PRIC4 often locates in the cytoplasm though in some conditions it translocates to the nucleus suggesting its dynamic nature within cells.
Biological function summary
PRIC4 interacts with other components to regulate cell orientation and movement. It is part of the Wnt signaling pathway complex where it stabilizes cell structures and supports cell communication. PRIC4 partners with other planar cell polarity components to influence the organization of cells within tissues particularly through its synaptic roles.
Pathways
PRIC4 participates in the Wnt and Hedgehog signaling pathways. These pathways play key roles in cell differentiation and proliferation. PRIC4 influences these processes through interactions with associated proteins like Dishevelled (Dvl) in the Wnt pathway. This interaction suggests PRIC4’s potential in modulating signal cascades that control tissue development and maintenance.
Disruptions involving PRIC4 may lead to disorders like epilepsy and certain kidney diseases. PRIC4 relates to epilepsy through its regulation of neuronal connections possibly working with proteins like synapsin in synaptic stability. In kidney disorders its role in cellular polarity and signaling implies a connection with proteins like nephrin which are essential for kidney function.