Abcam, ab119915, Anti-TPC2 antibody

Size: 100µg
Rabbit Polyclonal TPC2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human TPCN2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TPCN2. The exact immunogen used to generate this antibody is proprietary information.Q8NHX9

Properties and Storage Information:
Form-Lyophilized, Reconstitution-reconstitute with water at 200µL, Purification technique-Affinity purification Immunogen, Purification notes-ab119915 is purified by a peptide affinity column., Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TPC2 also known as Two-Pore Channel 2 functions as an ion channel that conducts calcium ions within acidic intracellular compartments like lysosomes and endosomes. The mass of TPC2 is approximately 92 kDa. This protein is found in a variety of tissues with notable expression in the immune system brain and heart. TPC2 operates by forming a channel across the membranes of these organelles helping regulate ionic balance and maintaining the function of the endolysosomal system.
Biological function summary
TPC2 regulates the release of calcium within cells influencing many cellular processes such as trafficking and signaling. TPC2 can participate in complex formation with other proteins within the endolysosomal system affecting the calcium dynamics there. By helping control intracellular calcium levels TPC2 contributes to processes like autophagy and membrane trafficking which are critical for proper cellular function and metabolism.
Pathways
TPC2 plays a part in calcium signaling and autophagy pathways. It modulates calcium responses associated with the activation of lysosomal channels that are vital in these pathways. In calcium signaling TPC2's regulation affects proteins like NAADP and IP3Rs which contribute to the modulation of intracellular calcium levels and downstream signaling events. These interactions highlight its role in maintaining cellular homeostasis and responsiveness to environmental cues.
TPC2 has connections to conditions such as neurodegenerative diseases and cancer. Abnormal TPC2 function can lead to altered calcium homeostasis affecting cellular processes and potentially leading to these diseases. Research reveals that in some tumors changes in TPC2 expression alter the behavior of cancer cells implicating it in cancer progression. The protein's role in neurodegeneration also links to Tau protein and amyloid beta pathways as disruptions in calcium signaling and lysosomal function can exacerbate such disorders.