Abcam, ab120011, AMN082 dihydrochloride, mGlu7 agonist

Size: 10mg / 50mg
MW 465.5 Da, Purity >98%. Potent, selective, orally active and brain penetrant mGlu7 receptor agonist. Potently inhibits cAMP accumulation and stimulates GTP binding (EC50 = 64-290 nM) in mGluR7 transfected cells. Selective over mGlu1, 2, 3, 4,5, 6, and 8, ionotropic receptors (up to 10 μM). Elevates plasma stress hormones *in vivo*. Induces mGlu7 receptor internalisation in dissociated hippocampal neurones.
Key facts
CAS number:97075-46-2,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:465.5 Da,
Molecular formula:C28H30Cl2N2,
PubChem:11698390,
Nature:Synthetic,
Solubility:Soluble in water to 5 mMSoluble in ethanol to 1 mMSoluble in DMSO to 100 mM,
Biochemical name:Amn082 dihydrochloride,
Biological description:Potent, selective, orally active and brain penetrant mGlu7 receptor agonist. Potently inhibits cAMP accumulation and stimulates GTP binding (EC50 = 64-290 nM) in mGluR7 transfected cells. Selective over mGlu1, 2, 3, 4,5, 6, and 8, ionotropic receptors (up to 10 μM). Elevates plasma stress hormones *in vivo*. Induces mGlu7 receptor internalisation in dissociated hippocampal neurones.,
Canonical smiles:C1=CC=C(C=C1)C(C2=CC=CC=C2)NCCNC(C3=CC=CC=C3)C4=CC=CC=C4.Cl.Cl,
InChi:InChI=1S/C28H28N2.2ClH/c1-5-13-23(14-6-1)27(24-15-7-2-8-16-24)29-21-22-30-28(25-17-9-3-10-18-25)26-19-11-4-12-20-26;;/h1-20,27-30H,21-22H2;2*1H,
InChiKey:YRQCDCNQANSUPB-UHFFFAOYSA-N,
IUPAC Name:N,N'-dibenzhydrylethane-1,2-diamine;dihydrochloride

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months