Abcam, ab120117, QX-314 bromide (N-Ethyllidocaine bromide), Na+ channel blocker

Size: 50mg / 100mg / 250mg
MW 343.3 Da, Purity >99%. A membrane impermeable quaternary lidocaine derivative. Blocks voltage-sensitive Na+ conductance when applied intracellularly. Soluble in 1 ml water to give specified mM/ml concentration.
Key facts
CAS number:21306-56-9,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:343.3 Da,
Molecular formula:C16H27BrN2O,
PubChem:9884487,
Nature:Synthetic,
Biochemical name:Lidocaine N-ethyl bromide,
Biological description:A membrane impermeable quaternary lidocaine derivative. Blocks voltage-sensitive Na+ conductance when applied intracellularly. Soluble in 1 ml water to give specified mM/ml concentration.,
Canonical smiles:CC[N+](CC)(CC)CC(=O)NC1=C(C=CC=C1C)C.[Br-],
InChi:InChI=1S/C16H26N2O.BrH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H,
InChiKey:DLHMKHREUTXMCH-UHFFFAOYSA-N,
IUPAC Name:[2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium;bromide

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Muscarinic acetylcholine receptors M4 (CHRM4) and M5 (CHRM5) are types of G protein-coupled receptors (GPCRs) that interact with the neurotransmitter acetylcholine. CHRM4 has a molecular mass around 49 kDa while CHRM5's mass is approximately 53 kDa. CHRM4 is expressed in areas like the cortex hippocampus and striatum while CHRM5 is found in regions like the basal forebrain and the thalamus. These receptors mediate different physiological responses through the modulation of intracellular signaling pathways.
Biological function summary
Muscarinic acetylcholine receptors are critical in regulating functions such as cognitive processing motor control and autonomic nervous system actions. They do not operate as part of a multi-protein complex but engage in signaling mechanisms after neurotransmitter binding. Both receptor types contribute to neural circuitry by activating phosphoinositide breakdown and modulating cyclic AMP levels.
Pathways
Muscarinic acetylcholine receptors participate in the cholinergic signaling pathway. This pathway is essential for neurotransmission in the central and peripheral nervous systems. Interaction with G proteins particularly Gi/o for CHRM4 and Gq/11 for CHRM5 allows these receptors to influence downstream effectors like phospholipase C. Other proteins related to this pathway include the nicotinic acetylcholine receptors that also bind acetylcholine to propagate neural signals.
Muscarinic acetylcholine receptors are linked to conditions like schizophrenia and Alzheimer's disease. CHRM4 appears connected to schizophrenia likely due to its role in modulating dopaminergic and glutamatergic neurotransmission. CHRM5 through its signaling pathways relates to Alzheimer’s impacting cognitive functions. Both receptors maintain interactions with proteins like the NMDA receptor in the context of these disorders influencing their pathophysiological roles.