Abcam, ab120600, Chelerythrine chloride, Cell-permeable protein kinase C inhibitor

Size: 5mg / 25mg
MW 383.8 Da, Purity >98%. Cell-permeable, selective inhibitor of protein kinase C (IC 50 = 0.66 μM); Competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Activates MAPK pathways, independent of PKC inhibition. Inhibits Bcl XL function (IC 50 = 1.5 μM) by displacing Bax binding, inducing apoptosis in several cancer cell lines.
Key facts
CAS number:3895-92-9,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:383.8 Da,
Molecular formula:C21H18ClNO4,
PubChem:72311,
Nature:Synthetic,
Solubility:Soluble in DMSO to 10 mMSoluble in water to 10 mM,
Biochemical name:Chelerythrine chloride,
Biological description:Cell-permeable, selective inhibitor of protein kinase C (IC50 = 0.66 μM); Competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Activates MAPK pathways, independent of PKC inhibition. Inhibits BclXL function (IC50 = 1.5 μM) by displacing Bax binding, inducing apoptosis in several cancer cell lines.,
Canonical smiles:C[N+]1=C2C(=C3C=CC(=C(C3=C1)OC)OC)C=CC4=CC5=C(C=C42)OCO5.[Cl-],
InChi:InChI=1S/C21H18NO4.ClH/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22;/h4-10H,11H2,1-3H3;1H/q+1;/p-1,
InChiKey:WEEFNMFMNMASJY-UHFFFAOYSA-M,
IUPAC Name:1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium;chloride

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months