Abcam, ab120687, Pitstop® 2, Novel cell-permeable clathrin inhibitor

Size: 5mg
Novel, selective, cell membrane permeable clathrin inhibitor. Competitively inhibits clathrin terminal domain to selectively inhibit clathrin mediated endocytosis (CME) (IC 50 = 12 µM for inhibition of amphiphysin association of clathrin TD). - 15µM of ab120687 sufficient to block compensatory endocytosis of neuronal presynaptic compartments.
Key facts
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:473.4 Da,
Molecular formula:C20H13BrN2O3S2,
PubChem:137254289,
Nature:Synthetic,
Solubility:Soluble in DMSO. Please refer to the Protocol Booklet for more information.,
Biochemical name:2-(1-Naphthylsulfonylamino)-5-[(Z)-4-bromobenzylidene]-2-thiazoline-4-one,
Biological description:Novel, selective, cell membrane permeable clathrin inhibitor. Competitively inhibits clathrin terminal domain to selectively inhibit clathrin mediated endocytosis (CME) (IC50 = 12 μM for inhibition of amphiphysin association of clathrin TD). Interferes with receptor mediated endocytosis (RME), entry of HIV and synaptic vesicle recycling.,
Canonical smiles:C1=CC=C2C(=C1)C=CC=C2S(=O)(=O)N=C3NC(=O)C(=CC4=CC=C(C=C4)Br)S3,
Isomeric smiles:C1=CC=C2C(=C1)C=CC=C2S(=O)(=O)N=C3NC(=O)/C(=C/C4=CC=C(C=C4)Br)/S3,
InChi:InChI=1S/C20H13BrN2O3S2/c21-15-10-8-13(9-11-15)12-17-19(24)22-20(27-17)23-28(25,26)18-7-3-5-14-4-1-2-6-16(14)18/h1-12H,(H,22,23,24)/b17-12-,
InChiKey:CGDLWHGPJPVPDU-ATVHPVEESA-N,
IUPAC Name:N-[(5Z)-5-[(4-bromophenyl)methylidene]-4-oxo-1,3-thiazolidin-2-ylidene]naphthalene-1-sulfonamide

Product details:
High concentrations of Pitstop ™ may interfere with fluorescence imaging due to a low emittance of the compound in the green channel. This fluorescence is not usually detectable if the cells have been first fixed and washed prior to imaging.
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Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. Pitstop® is a trademark of Freie Universitat Berlin, Newcastle Innovation Ltd. and Children's Medical Research Institute.

Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months