Abcam, ab121125, Anti-Myosin 18B antibody

Size: 100µL
Rabbit Polyclonal MY18B antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Unconventional myosin-XVIIIb aa 2400 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Unconventional myosin-XVIIIb aa 2400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8IUG5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Myosin 18B also known as MYO18B is a molecular motor protein involved in cellular movement and structure. This protein has a mass of approximately 229 kDa. It mainly facilitates actin binding and muscular contraction. Myosin 18B is expressed in skeletal muscle and cardiac muscle tissues and shows a presence in some non-muscle tissues suggesting diverse functions beyond muscle contraction.
Biological function summary
Myosin 18B plays an important role in maintaining the integrity of cellular and muscular structures. It is part of a complex that interacts with other cytoskeletal proteins contributing to cellular architecture. By localizing to the cytoskeleton Myosin 18B helps structurally support cells and tissues ensuring proper cellular organization and stability.
Pathways
Myosin 18B interacts with actin filaments within the cells which are pivotal in the regulation of cell shape and contraction. It participates in the Rho signaling pathway which controls actin cytoskeleton dynamics influencing cell adhesion and migration. Myosin 18B acts together with proteins like MYO9B in these pathways coordinating cellular responses to environmental and developmental signals.
Myosin 18B has a connection with certain muscular dystrophies and cancers. Mutations in the MYO18B gene have been linked to hypertrophic cardiomyopathy a disease characterized by thickening of the heart muscle. The protein's role in cancer is related to its interaction with the tumor suppressor protein APC indicating possible implications in tumor progression and metastasis. These associations with disease highlight the significance of further research into Myosin 18B's functions and mechanisms.