Abcam, ab121164, Anti-MDGA2 antibody

Size: 100µL
Rabbit Polyclonal MDGA2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MDGA2 aa 500-700.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MDGA2 aa 500-700. The exact immunogen used to generate this antibody is proprietary information.Q7Z553

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MDGA2 also known as MAM Domain-Containing Glycosylphosphatidylinositol Anchor 2 is a neural cell adhesion molecule that belongs to the Ig superfamily. This protein has a mass of approximately 109 kDa and is expressed mainly in the brain particularly in regions important for learning and memory processes. MDGA2 plays a mechanical role in neuronal development by interacting with axonal growth cones and facilitating cell-cell communication through its extracellular MAM domain.
Biological function summary
MDGA2 participates in synaptic modulation and plasticity. It acts outside of synapses modulating interactions between molecules involved in synaptogenesis. MDGA2 is not known to form a complex by itself but it is often functionally linked with neuroligins and other synapse-related proteins which impact neural circuitry organization. Its activity highlights its role in regulating neuronal connectivity influencing basic properties of synaptic transmission.
Pathways
MDGA2 plays significant roles in the glutamatergic signaling and neuronal development pathways. It impacts the way in which neurons form connections and strengthen synapses over time processes that are vital for cognitive functions. In these pathways MDGA2 interacts with proteins such as neurexins (NRXN) to stabilize or destabilize synaptic contacts adjusting neuronal network activity accordingly.
Abnormal MDGA2 function relates to neurodevelopmental disorders such as autism spectrum disorder and schizophrenia. Changes in MDGA2 levels or structure can disrupt normal synaptic function and plasticity possibly leading to altered connectivity patterns in the brain. Through these disorders MDGA2 is often investigated alongside other proteins like neuregulin 1 (NRG1) due to their combined effects on neurodevelopment and synaptic maintenance.