Abcam, ab121276, Anti-SELK antibody

Size: 100µL
Rabbit Polyclonal SELK antibody. Suitable for IHC-P, ICC, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SELENOK aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SELENOK aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9Y6D0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein SELK also known as selenoprotein K plays an important role in cellular processes. SELK is a small protein with a mass of about 11.4 kDa. It is characterized by the presence of the amino acid selenocysteine which is rare and important for its function. SELK produces in various tissues including heart skeletal muscle and liver. It locates in the endoplasmic reticulum membrane where it interacts with other proteins to contribute to molecular processes essential for cell homeostasis.
Biological function summary
SELK influences the regulation of calcium flux in cells affecting cellular signaling and immune responses. It is not a stand-alone actor but associates with other proteins to form multi-protein complexes that facilitate these cellular functions. SELK participates in processes like antioxidant defense and endoplasmic reticulum stress response which protects cells from damage. By modulating the immune response SELK plays an important role in maintaining balance in the immune system.
Pathways
This protein interacts in the oxidative stress pathways and plays a role in calcium signaling. In oxidative stress pathways SELK helps protect cells against reactive oxygen species maintaining cellular health. It works closely with proteins such as selenoprotein S and other antioxidant defense proteins. In calcium signaling SELK helps regulate calcium ion flow across cellular membranes supporting various cellular functions essential for those pathways.
SELK connects to cardiovascular diseases and autoimmune disorders. Its involvement in regulating immune responses and calcium flux associates with the pathogenesis of these conditions. In cardiovascular diseases abnormal SELK expression may contribute to heart abnormalities by interacting with calcium-modulating proteins like calnexin. In autoimmune disorders a dysregulated SELK function may affect immune balance and lead to immune system malfunction. Understanding SELK interactions gives insights into these diseases and potential therapeutic approaches.