Abcam, ab121316, Anti-SHROOM4 antibody

Size: 100µL
Rabbit Polyclonal SHROOM4 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SHROOM4 aa 1150-1300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SHROOM4 aa 1150-1300. The exact immunogen used to generate this antibody is proprietary information.Q9ULL8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle, Store undiluted

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SHROOM4 also known as KIAA1202 is a microtubule-associated protein with a mass of approximately 160 kDa. It plays a role in cytoskeletal organization by interacting with various cytoskeletal components. This protein is expressed mainly in neural tissues suggesting its involvement in neural development and function. SHROOM4's function in the cytoskeleton involves influencing the assembly and stability of actin filaments which are critical in maintaining the shape and motility of the cells.
Biological function summary
SHROOM4 participates in the regulation of cell morphogenesis particularly in the development of polarized cellular structures. SHROOM4 often associates with the actomyosin complex thereby influencing cell shape and polarity. By participating in these cellular processes SHROOM4 affects the organization and positioning of cells within tissues contributing to the proper formation of organ structures during development. Its interactions with other members of the SHROOM protein family enable it to execute its functions within the cellular architecture effectively.
Pathways
SHROOM4 is involved in the planar cell polarity pathway which is essential for coordinated orientation and arrangement of cells in the epithelial layer. This pathway also includes other key proteins like VANGL2. Besides SHROOM4 contributes to the actin cytoskeleton organization pathway where it engages with proteins like RHOA to modify actin dynamics. These interactions ensure precise cellular alignment and positioning critical for tissue and organ architecture during embryonic development.
SHROOM4 has connections to neurodevelopmental disorders such as epilepsy. Mutations in SHROOM4 correlate with disruption in neural circuit formation contributing to epileptic manifestations. Additionally SHROOM4's role in cytoarchitecture links it with conditions like X-linked intellectual disability. Proteins like ARHGEF6 accompany SHROOM4 in the disease mechanisms highlighting its involvement in maintaining cellular integrity and function in neural cells. Study of these associations reveals SHROOM4's significance in neurological health and disease.