Abcam, ab121408, Anti-C12orf35 antibody

Size: 100µL
Rabbit Polyclonal C12orf35 antibody. Suitable for IHC-P, ICC and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RESF1 aa 1550 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RESF1 aa 1550 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9HCM1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C12orf35 also known as FLJ22582 is a protein coding gene with a predicted molecular mass of around 52 kDa. Its exact function on a mechanical level is not fully understood but research suggests it plays a role in transcriptional regulation. The protein does not have a well-defined structure currently which makes detailed mechanical understanding challenging. C12orf35 is expressed in various tissues including the brain liver and spleen suggesting a widespread functional role across the human body.
Biological function summary
C12orf35 has been implicated in transcriptional regulation associating with transcriptional complexes to modulate gene expression. Evidence suggests it participates indirectly in RNA polymerase II-dependent transcription though the exact mechanisms and partners remain to be fully identified. Its broad expression in multiple tissues points to a generalized function across numerous biological processes but further clarification is needed through ongoing studies to pinpoint its precise involvement and interactions.
Pathways
C12orf35 figures in the transcriptional regulation involving RNA polymerase II. This association positions it adjacent to pathways such as signal transduction. It potentially interfaces with proteins involved in these processes like transcriptional activators and repressors further influencing gene expression and cellular responses. Researchers continue to explore the specific pathways seeking to understand better how C12orf35 coordinates within cellular networks and what implications this has for cellular function.
Research shows that changes in C12orf35 expression or function could potentially link to cancer and neurodegenerative conditions. Altered expression profiles in cancer tissues suggest a role in tumorigenesis potentially through the deregulation of cell growth signaling pathways. Furthermore its wide expression in the nervous system implies involvement with neurological disorders where misregulation might impact neural function. Understanding connections with proteins involved in these diseases is ongoing and researchers are looking at key players in cancer and neurodegenerative diseases to better describe C12orf35’s role in these conditions.