Abcam, ab121410, Anti-KANK4 antibody

Size: 100µL
Rabbit Polyclonal KANK4 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human KANK4 aa 350-550.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human KANK4 aa 350-550. The exact immunogen used to generate this antibody is proprietary information.Q5T7N3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
KANK4 also referred to as KN motif and ankyrin repeat domain-containing protein 4 is a protein that plays an important role in cellular functions. It has a molecular mass of approximately 45 kDa. This protein is expressed in various tissues with notable levels in the kidney and brain. Its presence in these tissues suggests a significant role in cellular structural maintenance and signaling processes. KANK4 contributes to the organization of the cytoskeleton and participates in cellular adhesion.
Biological function summary
KANK4 functions as a scaffolding protein that connects other proteins to the cytoskeleton aiding in maintaining cell shape and motility. It is a part of a larger protein complex that includes elements involved in actin filament assembly. This functional role is important for cellular responses to external stimuli and mechanical stress. KANK4's interaction with such protein complexes can influence cell motility and structural integrity reflecting its versatility in multiple biological contexts.
Pathways
KANK4 integrates into pathways like the Rho GTPase signaling pathway which is vital for cytoskeletal rearrangement and cell movement. It is associated with actin-binding proteins and Rho-associated coiled-coil containing protein kinase (ROCK) indicating its role in signal transduction and changes in cell shape. These pathways highlight KANK4’s involvement in cellular dynamics and its influence on other proteins related to cytoskeletal functions.
KANK4 has associations with kidney diseases particularly those involving impaired glomerular function. Alterations or dysregulation in KANK4 can disrupt cellular architecture impacting kidney function and leading to pathological states. Additionally deficiencies in KANK4 expression have been linked to neurodevelopmental disorders due to its interactions with proteins like Ankyrin which is essential for neuronal connectivity and stability. These connections indicate the potential impact of KANK4 in specific tissues and highlight its significance in health and disease.