Abcam, ab121486, Anti-ZNF516 antibody

Size: 100µL
Rabbit Polyclonal ZNF516 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF516 aa 600-750.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ZNF516 aa 600-750. The exact immunogen used to generate this antibody is proprietary information.Q92618

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF516 also known as zinc finger protein 516 is a transcription factor with a molecular weight of approximately 122 kDa. It contains zinc finger motifs that allow it to bind DNA and regulate transcription. ZNF516 expresses widely in human tissues with notable presence in the brain heart and skeletal muscle. Its expression levels suggest its involvement in various cellular processes across different tissue types.
Biological function summary
The zinc finger protein 516 plays a significant role in transcriptional regulation controlling the expression of genes involved in energy metabolism and adipogenesis. This protein acts as part of larger transcription complexes interacting with other proteins to exert its effects on target genes. Proper function of ZNF516 is critical for maintaining cellular energy balance and processes related to fat cell development.
Pathways
Zinc finger protein 516 integrates into the pathways regulating energy metabolism and adipocyte differentiation. It heavily influences the PPARγ pathway essential for fat storage and adipocyte maturation. ZNF516 also interacts with other transcription factors like C/EBPα highlighting its role in adipogenic differentiation and energy homeostasis. Its regulatory actions align it with other key metabolic pathways in the body.
Improper function or expression of ZNF516 may contribute to metabolic disorders such as obesity and type 2 diabetes. Abnormalities in the regulation of this protein could disrupt the balance of energy storage and utilization leading to metabolic dysfunction. ZNF516's interaction with proteins like PPARγ known for its role in metabolic syndrome highlights its potential impact on these conditions. Understanding these connections might offer new therapeutic insights into treating metabolic diseases.