Abcam, ab121574, Anti-ERGIC1 antibody

Size: 100µL
Rabbit Polyclonal ERGIC1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ERGIC1 aa 50-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ERGIC1 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.Q969X5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The ER-Golgi Intermediate Compartment 1 (ERGIC1) is an important protein that functions mechanically in protein sorting and trafficking between the endoplasmic reticulum (ER) and the Golgi apparatus. Known also as ERGIC-53 ERGIC-1 is a significant component involved in shuttling cargo proteins ensuring proper delivery through secretory pathways. It weighs approximately 59 kDa and is expressed in various cell types found extensively in the ER-Golgi interfaces.
Biological function summary
The movement processes mediated by ERGIC-1 maintain the central operations of intracellular transport. It plays an important role in the cycling and movement of glycoproteins influencing different cellular activities. ERGIC1 is part of a larger complex involved in vesicular transport and interacts with several coat protein complexes. These activities are vital for the modulation of glycoprotein processing and trafficking linking its function intricately with cellular transport mechanisms.
Pathways
Researchers have linked ERGIC-1 to important activities like the secretory pathway and protein synthesis pathways. Within these pathways it coordinates with proteins such as COPI and COPII ensuring efficient vesicle formation and cargo delivery between the ER and Golgi. Efficient functioning of these pathways is necessary for the regulation of protein synthesis and secretion directly impacting cellular homeostasis.
ERGIC-1 plays a role in conditions affecting protein transport and folding. Misregulation or mutations in ERGIC1 can lead to disorders such as congenital disorders of glycosylation. Additionally researchers observe that it influences pathways involving proteins like lysosomal alpha-glucosidase connecting it to diseases like Pompe disease. Understanding these connections highlights ERGIC-1's importance in maintaining cellular function and health.