Abcam, ab121592, Anti-STARD3NL antibody

Size: 100µL
Rabbit Polyclonal STARD3NL antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human STARD3NL aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human STARD3NL aa 1-100. The exact immunogen used to generate this antibody is proprietary information.O95772

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
STARD3NL also known as StAR-related lipid transfer domain containing 3 N-terminal like is a protein that functions mechanically to transfer lipids between membranes. This protein has an estimated mass of approximately 47 kDa. It is expressed in multiple tissues with high levels found in the liver and kidneys. STARD3NL performs its functions within the cell by interacting with membranes affecting lipid metabolism.
Biological function summary
STARD3NL plays a role in regulating lipid transport and homeostasis. It is involved in cellular processes that ensure the proper distribution of lipids which is essential for membrane integrity and energy storage. STARD3NL may function as part of a larger protein complex that facilitates these processes. Its exact role within the complex could be linked to the modulation of cholesterol distribution.
Pathways
STARD3NL is involved in the dynamic lipid metabolism and transport pathways. It participates in the intracellular lipid transport pathway important for ensuring lipid availability. STARD3NL works alongside proteins like STARD3 which also belong to the StAR-related lipid transfer (START) domain-containing family. This cooperation influences the function and pathways related to cholesterol homeostasis.
STARD3NL has links to disorders related to cholesterol metabolism and lipid accumulation. Its dysregulation may contribute to conditions like Niemann-Pick disease where cholesterol transport becomes impaired. In this context STARD3NL interacts with proteins like NPC1 and NPC2 which are important for the regulation of intracellular cholesterol trafficking and are implicated in lipid storage diseases.