Abcam, ab121685, Anti-ZNF750 antibody

Size: 100µL
Rabbit Polyclonal ZNF750 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF750 aa 600 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ZNF750 aa 600 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q32MQ0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF750 also known as zinc finger protein 750 is a transcription factor with a molecular weight of approximately 80 kDa. It contains zinc finger motifs that allow it to bind DNA and regulate gene expression. This protein is primarily expressed in the epidermis where it plays a critical role in cellular differentiation. ZNF750 acts by modulating the expression of genes involved in the maintenance and function of the skin barrier.
Biological function summary
This transcription factor influences the differentiation of keratinocytes the predominant cell type in the epidermis. ZNF750 controls the terminal differentiation programs by inducing the expression of differentiation-specific genes. It functions in part of a larger transcriptional complex interacting with other transcription factors and co-regulators to execute its functions. These interactions dictate the precise genetic output necessary for maintaining skin integrity.
Pathways
ZNF750 plays a part in the epidermal differentiation complex pathway. This pathway coordinates the transition of keratinocytes from proliferative basal cells to differentiated cells. The activity of ZNF750 closely links with other proteins like KLF4 and GRHL3 which are also important in epidermal regulation. Together these proteins form a network that supports skin development and repair processes.
Mutations or dysfunctions in ZNF750 have associations with skin-related conditions such as psoriasis and seborrheic dermatitis. Aberrant expression or mutations can disrupt normal keratinocyte differentiation leading to hyperproliferative skin disorders. ZNF750's activity connects with other factors including c-MYC which is involved in cellular proliferation highlighting its role in maintaining the balance between cell proliferation and differentiation in the epidermis.