Abcam, ab121695, Anti-RBM33 antibody

Size: 100µL
Rabbit Polyclonal RBM33 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human RBM33 aa 600-750.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RBM33 aa 600-750. The exact immunogen used to generate this antibody is proprietary information.Q96EV2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RBM33 also known as RNA Binding Motif Protein 33 is a protein responsible for binding RNA molecules during their post-transcriptional modifications. It has a mass of approximately 68 kDa. Scientists have observed that RBM33 is expressed in various tissues including the brain liver and kidney indicating it has a widespread presence in the human body. This protein's ability to interact with RNAs situates it as a significant player in numerous cellular processes related to RNA metabolism.
Biological function summary
The function of RBM33 is integral to RNA splicing an activity necessary for the maturation and functionality of messenger RNA. RBM33 interacts with other proteins to form complexes that regulate alternative splicing events which adapt gene expression patterns to meet cellular needs. This regulatory role highlights its importance in modifying gene instructional sequences and maintaining protein diversity in cells. Research suggests this protein's role is not isolated and frequently involves teamwork with splicing factors to achieve precise RNA modifications.
Pathways
RBM33 operates within the framework of the RNA splicing pathway and influences the processing of pre-mRNA. It aligns with heterogeneous nuclear ribonucleoproteins (hnRNPs) and splicing factors like SF3B1 to ensure the accuracy of splicing activities. RBM33 is not limited to just RNA splicing but also plays a role in the RNA transport pathway impacting how RNA is dispatched within a cell for translation or degradation. This functionality suggests cooperation with proteins related to RNA processing and transport contributing to a complex network of RNA regulatory mechanisms.
Studies connect RBM33 to neurological conditions such as epilepsy and neurodegenerative diseases. Abnormal expressions and mutations of RBM33 can influence the splicing of genes associated with these disorders potentially exacerbating disease symptoms or progression. Furthermore research highlights its link with the related protein RBFOX1 as altered interactions between these proteins may contribute to neurological disease mechanisms. Scientists actively study RBM33 to better understand its potential as a therapeutic target for managing RNA splicing-related abnormalities in these conditions.