Abcam, ab121750, Anti-FAM83G/PAWS1 antibody

Size: 100µL
Rabbit Polyclonal FAM83G/PAWS1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 7 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein FAM83G also known as PAWS1 is an important regulator in cellular processes. It boasts a mass of approximately 72 kDa and is expressed in various tissue types suggesting a role in broad physiological contexts. FAM83G/PAWS1 acts mechanically by interacting with key cellular machinery which influences various signaling pathways important for maintaining cellular homeostasis.
Biological function summary
The protein interacts with important signaling complexes including the Wnt pathway components. FAM83G/PAWS1 is involved in modulating cellular response to external signals contributing to development and cellular differentiation. It binds to other proteins facilitating the assembly of complexes necessary for effective signal transduction which can impact how cells grow and evolve.
Pathways
FAM83G/PAWS1 is a significant player in the Wnt and TGF-beta signaling cascades. It interacts with proteins such as SMAD2/3 and Gbeta like proteins linking these pathways to broader cellular responses. These interactions ensure the fine-tuning of essential processes like cell positioning during development and signal synchronization in the cellular environment.
FAM83G/PAWS1 shows potential connections to cancer and fibrotic diseases. Its regulation of pathways like Wnt can impact oncogenesis making it a target for cancer research. The protein can also relate to abnormal fibroblast behavior in fibrosis possibly interacting with other proteins such as SMAD3 which is known to play a role in fibrotic response. Understanding FAM83G/PAWS1's role aids in dissecting its contribution to these complex disorders.