Abcam, ab121771, Anti-WDR67 antibody

Size: 100µL
Rabbit Polyclonal WDR67 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TBC1D31 aa 600-750.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TBC1D31 aa 600-750. The exact immunogen used to generate this antibody is proprietary information.Q96DN5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
WDR67 also known as WD repeat-containing protein 67 is a protein involved in cellular mechanics with a mass of approximately 158 kDa. It localizes in the cytoplasm and nucleus indicating roles in different cellular processes. This protein belongs to the WD repeat protein family recognized for their role in forming protein-protein interactions. Evidence shows WDR67 is ubiquitously expressed in various tissues with higher levels in neuronal and muscular tissues suggesting functional importance in these areas.
Biological function summary
The function of WDR67 integrates into several cellular activities through its role as part of larger multiprotein complexes. These complexes participate in processes such as signal transduction and cell cycle progression. WDR67 interacts with other proteins to regulate protein assembly and cellular organization. This role lists it as an adapter or scaffold protein facilitating the correct localization and function of its binding partners within cells.
Pathways
WDR67 plays roles in the Wnt signaling and cell cycle control pathways. It acts by modulating these pathways affecting cellular growth and proliferation. It interacts with key signaling proteins such as beta-catenin within the Wnt pathway which is critical for regulating gene expression and maintaining cellular health. These interactions help modulate cellular responses to various developmental cues and stress conditions.
WDR67 is linked to Meckel-Gruber syndrome and Joubert syndrome suggesting a role in ciliopathy disorders. These disorders occur due to WDR67’s interactions with other ciliary proteins like MKS1. Mutations or disruptions in WDR67 can lead to improper functioning of cilia the cell's sensory and signaling structures contributing to the developmental abnormalities observed in these syndromes. Understanding its role can provide insights into the treatment or management of these conditions.