Abcam, ab121821, Anti-MRPL41 antibody

Size: 100µL
Rabbit Polyclonal MRPL41 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MRPL41 aa 50 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MRPL41 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8IXM3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MRPL41 also known as mitochondrial ribosomal protein L41 plays an important role in protein synthesis within the mitochondria. This protein is a component of the large 39S subunit of mitochondrial ribosome with a molecular mass estimated around 25 kDa. It is expressed primarily in mitochondria across various tissues implying a wide-ranging function associated with cellular energy production and metabolism.
Biological function summary
MRPL41 interacts in mitochondrial ribosome assembly where it helps in the production of proteins necessary for mitochondrial function. It is a segment of the mitochondrial ribosome working alongside other ribosomal proteins in a specialized complex. These proteins ensure that the mitochondria can synthesize their own proteins which are vital for the organelle's energy-converting activities. MRPL41 thereby is instrumental in maintaining the integrity of the mitochondrial protein synthesis machinery.
Pathways
MRPL41 is embedded within the mitochondrial translation and oxidative phosphorylation pathways which are essential for cellular energy supply. This protein forms connections with other mitochondrial ribosomal proteins such as MRPL2 contributing to the proper function of the electron transport chain. Disruption in these pathways could lead to significant cellular dysfunctions due to mitochondrial malfunction.
MRPL41 is associated with mitochondrial diseases which can result from failures in mitochondrial protein synthesis. These disorders often present as metabolic issues or multisystemic anomalies. MRPL41 has connections to proteins like MRPS22 which is also involved in the mitochondrial ribosome and is implicated in similar disorders. Understanding MRPL41's role gives insights into potential therapeutic targets for mitochondrial-related diseases.