Abcam, ab121831, Anti-SAMD12 antibody

Size: 100µL
Rabbit Polyclonal SAMD12 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Sterile alpha motif domain-containing protein 12 aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Sterile alpha motif domain-containing protein 12 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.Q8N8I0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SAMD12 short for Sterile Alpha Motif Domain Containing 12 has a mechanical role in cellular processes and protein interactions. It is a protein with a mass of approximately 105 kDa. SAMD12 expression occurs broadly across human tissues with higher presence noted in the brain and testis. This protein belongs to the family of proteins containing sterile alpha motifs which are known for their involvement in protein-protein interactions.
Biological function summary
SAMD12 functions as a mediator in cellular signaling and communication. It participates in processes that regulate gene expression and cellular structure contributing to neuronal development and maintenance. Although SAMD12 is not part of a large complex it interacts with diverse proteins that aid in stabilizing cellular architecture and signaling networks.
Pathways
SAMD12 has significant interactions within the cellular signaling and development domains. It plays roles in the Wnt signaling pathway and neurodevelopmental pathways. SAMD12 interacts with proteins such as beta-catenin in the Wnt pathway influencing cellular proliferation and differentiation. Through these pathways SAMD12 connects to various proteins that coordinate cellular growth and structural integrity.
SAMD12 has associations with neurodegenerative disorders and certain cancers. In neurological contexts abnormal SAMD12 expression links to conditions like hereditary spastic paraplegia where it may interact with proteins like SPAST affecting neuronal function. SAMD12's involvement in cancers relates to its role in cellular signaling pathways that regulate cell growth and division suggesting its influence in tumorigenesis processes.