Abcam, ab121832, Anti-RRP15 antibody

Size: 100µL
Rabbit Polyclonal RRP15 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RRP15 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RRP15 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q9Y3B9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RRP15 also known as Ribosomal RNA Processing 15 Homolog is a protein involved in ribosome biogenesis. It has a molecular mass of approximately 27 kDa. This protein is present mainly in the nucleolus a substructure of the nucleus in eukaryotic cells. RRP15 participates mechanically in the processing and maturation of ribosomal RNA (rRNA) essential for forming effective ribosomes. By interacting with other proteins and rRNA it plays a direct role in the assembly of the ribosomal subunit.
Biological function summary
RRP15 is part of a large ribonucleoprotein complex involved in the pre-rRNA processing within the nucleolus. It acts as a factor in the ribosome assembly line influencing the synthesis and maturation of the 60S ribosomal subunit. By coordinating with other ribosome biogenesis proteins RRP15 ensures proper ribosomal function which is necessary for protein synthesis. Its interactions are critical in maintaining the pace and accuracy of ribosome assembly assisting in cellular growth and proliferation.
Pathways
RRP15 is integral to the ribosome biogenesis pathway and is related to the cell growth and division pathways. It interacts with other ribosomal assembly proteins such as Nop16 and Noc2 to facilitate correct formation of ribosomal subunits. The protein’s activity connects with the RNA transcription and processing influencing not just ribosome assembly but also the overall efficiency of protein translation. RRP15's function in these pathways highlights its importance in maintaining cellular homeostasis.
The role of RRP15 in ribosome biogenesis links to cancer and ribosomopathies. Disruptions in normal RRP15 function may lead to abnormal cell proliferation seen in certain cancers. Its association with other ribosome assembly factors like Dyskerin can contribute to these pathological conditions. Moreover alterations in RRP15 could relate to disorders in ribosome production impacting cellular growth and leading to complex symptoms in conditions like Diamond-Blackfan anemia.