Abcam, ab121943, Anti-WEE2 antibody

Size: 100µL
Rabbit Polyclonal WEE2 antibody. Suitable for IHC-P, ICC and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human WEE2 aa 300-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human WEE2 aa 300-400. The exact immunogen used to generate this antibody is proprietary information.P0C1S8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
WEE2 also known as WEE kinase homolog 2 or oocyte-specific serine/threonine-protein kinase is a protein expressed mainly in oocytes. It has a mass of approximately 58 kDa. WEE2 functions as a cell cycle regulator that has a significant role in controlling the progression of cells through mitosis. The protein achieves this by phosphorylating and inactivating cyclin-dependent kinases (CDKs) specifically CDK1 which is necessary for cell cycle progression. This regulatory mechanism ensures proper timing and coordination during the cell cycle.
Biological function summary
The regulation of oocyte meiotic arrest and maturation involves WEE2. This protein is a part of regulatory complexes known to maintain oocytes in meiotic prophase arrest until hormonal cues signal resumption of the cell cycle. Proper function of WEE2 is vital for the maintenance of genomic integrity and viability of the oocyte. By controlling entry into M-phase WEE2 provides a safeguard against premature oocyte maturation ensuring that only developmentally ready oocytes proceed through meiosis.
Pathways
WEE2 plays significant roles in the mitosis and cell cycle control pathways. It is closely related to CDK1 and through its regulatory function influences the Cyclin B1/CDK1 complex that is critical for mitotic entry. WEE2 interacts with other pathways that involve cell cycle checkpoints ensuring that any DNA replication issues are addressed before mitosis proceeds. This interaction maintains genomic stability and prevents aneuploidy.
WEE2 has been linked to reproductive disorders such as female infertility specifically related to oocyte maturation defects. Mutations or dysregulation in WEE2 can impair its kinase activity affecting the proper progression of meiosis. Additionally improper WEE2 function may contribute to cancer development where cell cycle control is lost. WEE2 interacts with TP53 a protein important in cancer pathways further highlighting its significance in disease contexts.