Abcam, ab121945, Anti-C1orf106/INAVA antibody

Size: 100µL
Rabbit Polyclonal C1orf106/INAVA antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human INAVA aa 250-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human INAVA aa 250-400. The exact immunogen used to generate this antibody is proprietary information.Q3KP66

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C1orf106 also known as INAVA is a protein with a predicted mass of about 33 kDa. It plays roles mechanically within cells by implicated interacting with cellular junctions and regulating cell adhesion. The expression of C1orf106 occurs high in epithelial tissues notably in the gastrointestinal tract. It may modulate the integrity of epithelial barriers which has implications for tissue signaling and structure.
Biological function summary
The function of C1orf106 is related to cellular adhesion and barrier maintenance which is essential for proper tissue structure and function. It participates in forming protein complexes that dynamically adjust to cellular environments. In intestinal epithelial cells the presence of C1orf106 is important for maintaining tight junctions' stability influencing how cells adhere to each other and communicate across barriers.
Pathways
C1orf106 interacts with cellular pathways that regulate the immune response and epithelial integrity. One key pathway involves the modulation of inflammatory responses which is significant for immune epithelial homeostasis. It interacts with proteins such as NFKB facilitating controlled immune signaling cascades which plays roles in defense mechanisms and maintaining tissue integrity under stress.
C1orf106's function links to inflammatory bowel diseases like Crohn's disease and ulcerative colitis. The protein's role in maintaining epithelial barrier integrity makes it a potential contributor to the pathogenesis of these disorders. It has associations with other proteins involved in inflammatory pathways including IL-10 a cytokine known for its regulatory functions in the immune system. This connection suggests that alterations in C1orf106 expression or function may disrupt epithelial barriers leading to or exacerbating these inflammatory conditions.