Abcam, ab122011, Anti-FLG2 antibody

Size: 100µL
Rabbit Polyclonal FLG2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FLG2 aa 250-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human FLG2 aa 250-400. The exact immunogen used to generate this antibody is proprietary information.Q5D862

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FLG2 also known as Filaggrin-2 is a protein involved in skin barrier function. It weighs approximately 248 kilodaltons and expresses mainly in the epidermis particularly in the stratum corneum. Its structure includes several repeat units similar in domain composition to the filaggrin protein which indicates its important roles in epidermal differentiation and hydration.
Biological function summary
The FLG2 protein provides structural support essential for skin integrity and contributes to preventing water loss. It associates with keratin filaments as part of the epidermal cornified envelope. The protein helps maintain skin hydration by breaking down into free amino acids which improve skin moisture. FLG2 interacts with other proteins like filaggrin suggesting overlapping functions in skin homeostasis.
Pathways
The FLG2 protein significantly impacts the skin barrier formation and repair processes. It participates in the epidermal differentiation complex (EDC) pathway and the key hydration pathway. FLG2 shares functional pathways with the filaggrin protein which also plays a role in forming the skin barrier by aggregating keratin filaments and releasing amino acids that maintain hydration and acid mantle of the skin.
FLG2 associates with skin conditions such as atopic dermatitis and ichthyosis vulgaris. Mutations or reduced expression in the FLG2 gene compromise the skin barrier leading to increased susceptibility to these conditions. In the context of atopic dermatitis its interaction with the filaggrin protein becomes apparent as both proteins being together or separately altered can exacerbate barrier defects highlighting their essential role in maintaining skin health.