Abcam, ab122131, Anti-HEATR6 antibody

Size: 100µL
Rabbit Polyclonal HEATR6 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human HEATR6 aa 1050 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human HEATR6 aa 1050 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q6AI08

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HEATR6 also known as "HEAT repeat containing protein 6" is a protein with a molecular mass of approximately 120 kDa. It has several HEAT repeat sequences which are recognized for mediating assembly and transport processes within cells. The expression of HEATR6 is found in multiple tissues with higher levels observed in the lungs liver and kidneys. These characteristics suggest it plays a role in diverse cellular functions leveraging its repeat sequences for interactions with other cellular components.
Biological function summary
HEATR6 contributes to cellular and molecular processes by acting as a scaffold protein. This role involves supporting the formation of multi-protein complexes essential for maintaining cellular structure and function. HEATR6 takes part in assembling ribonucleoprotein particles important for RNA processes. By aiding in the organization of these complexes HEATR6 ensures cellular homeostasis and efficient genetic information flow.
Pathways
HEATR6 interacts within the RNA splicing and transport pathways. Its role in these pathways involves coordination with other proteins like SF3B1 and U2AF2 which participate in pre-mRNA splicing. By facilitating RNA processing through these interactions HEATR6 ensures that pre-mRNA is correctly modified and transported a critical step for gene expression. This alignment with important pathways highlights HEATR6's significance in genetic and molecular fidelity.
Abnormalities in HEATR6 expression or function have associations with certain cancers including lung cancer. Experimental evidence indicates that its interaction with other proteins like HSP90 plays a part in cancer cell proliferation. Furthermore dysfunctional HEATR6 might link to neurodegenerative disorders where protein misfolding occurs. The involvement with key proteins and pathologies highlights the potential of HEATR6 as a clinical marker or therapeutic target in specific diseases.