Abcam, ab122188, Anti-SPOCD1 antibody

Size: 100µL
Rabbit Polyclonal SPOCD1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SPOCD1 aa 950-1100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SPOCD1 aa 950-1100. The exact immunogen used to generate this antibody is proprietary information.Q6ZMY3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SPOCD1 also known as SPOC domain-containing protein 1 is a protein with a molecular mass of approximately 105 kDa. This protein plays an important mechanical role in transcriptional regulation by influencing the chromatin state. SPOCD1 appears in the nucleus of cells and exhibits expression in tissues including the testes and adrenal glands. Its involvement is significant in processes requiring DNA-templated regulation.
Biological function summary
SPOCD1 acts as a part of large transcriptional complexes influencing gene expression through modification of chromatin structure. It interacts with other chromatin-associated proteins which assists in promoting or repressing transcription depending on the required cellular context. These interactions suggest SPOCD1's role as a mediator connecting transcription factors to chromatin remodeling machinery impacting gene activity directly.
Pathways
SPOCD1 is involved in pathways such as the regulatory pathway for RNA polymerase II-mediated transcription. It works closely with proteins like HDAC1 and components of the SWI/SNF complex that facilitate chromatin remodeling. These pathways highlight its role in modulating the access of transcription machinery to DNA highlighting its importance in maintaining normal transcriptional flow within cells.
SPOCD1 exhibits connections to cancer and infertility. Altered expression or mutations in SPOCD1 have links to tumorigenesis where the deregulated control of gene transcription may lead to uncontrolled cell proliferation. Moreover in the context of infertility SPOCD1 plays a role in germ cell development and its dysregulation can impact gametogenesis. These associations also involve proteins like BRD4 and DDX4 which work in concert with SPOCD1 to help maintain cellular and developmental processes.