Abcam, ab122223, Anti-LBH antibody

Size: 100µL
Rabbit Polyclonal LBH antibody. Suitable for IHC-P, ICC and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human LBH aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human LBH aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q53QV2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LBH also known as limb-bud and heart protein is a small protein with an approximate mass of 47 kDa. It plays a critical role in cell signaling and development processes by functioning as a transcriptional regulator impacting gene expression. Researchers discovered LBH's expression in several tissues including limb buds the heart and various epithelial tissues. This suggests its involvement in early developmental stages and tissue differentiation.
Biological function summary
LBH influences the development of tissues by modulating gene expression during embryonic growth. It operates as part of a transcriptional complex that interacts with other transcription factors and cofactors. The influence of LBH on cellular differentiation aligns with its expression in developing organs suggesting its role in establishing cellular identities and organogenesis.
Pathways
LBH integrates into signaling pathways related to developmental regulation such as the Wnt signaling pathway and TGF-beta pathway. LBH functions in conjunction with proteins like beta-catenin within the Wnt pathway which is important for cellular proliferation and differentiation. These pathways ensure a coordinated pattern of development linking LBH's activity to broader signaling networks that govern embryogenesis and tissue formation.
Alterations in LBH expression have connections with congenital heart defects and certain cancers illustrating its role in human health. Changes in LBH function or levels may disrupt normal development leading to conditions like atrial septal defects connected to aberrant interactions with transcription factors like T-box proteins. Furthermore its involvement in cancers suggests a link with proteins involved in cell cycle regulation hinting at potential therapeutic targets.