Abcam, ab122229, Anti-SLC4A10 antibody

Size: 100µL
Rabbit Polyclonal SLC4A10 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLC4A10 aa 600-700.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SLC4A10 aa 600-700. The exact immunogen used to generate this antibody is proprietary information.Q6U841

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SLC4A10 also known as NCBE (Na+-driven Cl-/HCO3- exchanger) is a member of the SLC4 family of bicarbonate transporters. It has a molecular mass of approximately 121 kDa. This protein functions in the exchange of bicarbonate (HCO3-) and chloride (Cl-) ions in cells and tissues facilitating the regulation of intracellular pH and bicarbonate homeostasis. SLC4A10 is strongly expressed in the brain particularly in structures like the cerebellum and hippocampus and is also present in other tissues such as the eyes and intestines. Its expression pattern indicates its role in specialized physiological processes requiring ion balance.
Biological function summary
The functions of SLC4A10 are integral to neuronal ion balance and signaling. It transports ions across membranes contributing to the maintenance of pH in neural tissues important for neurotransmission and neuronal excitability. SLC4A10 does not function as part of a larger protein complex but interacts with other ion transport systems to maintain cellular ion homeostasis. Its activity ensures neurons efficiently communicate and respond to stimuli by modulating synaptic activity and plasticity supporting normal brain functions.
Pathways
SLC4A10 plays roles in acid-base balance and ion transport pathways. It contributes significantly to the bicarbonate reclamation pathway which maintains pH balance within the central nervous system. This exchanger closely interacts with other transport proteins like SLC4A3/Band 3 and SLC4A7 to coordinate bicarbonate transport. The coordinated activity among these proteins allows fine-tuning of cellular ion exchange regulation pivotal in maintaining neurotransmitter release and responsive neural activity.
SLC4A10 has associations with neurological conditions such as epilepsy and migraine. Studies have highlighted that dysfunctional SLC4A10 may lead to improper ion homeostasis which can predispose individuals to these disorders. Mutations or dysregulation of this protein can disrupt the ion balance within neurons leading to increased susceptibility to seizures and migraines. In the context of these disorders SLC4A10 may interact with other neuronal proteins such as the GABA transporter SLC6A1 affecting inhibitory signaling pathways and contributing to pathological neuronal excitability.