Abcam, ab122273, Anti-METTL8 antibody

Size: 100µL
Rabbit Polyclonal METTL8 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human METTL8 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human METTL8 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q9H825

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
METTL8 also known as Methyltransferase-like protein 8 is an enzyme that catalyzes the methylation of RNA molecules. It belongs to the larger family of methyltransferases which are essential for various methylation processes. METTL8 has a molecular mass of approximately 67 kDa. The expression of METTL8 is observed in multiple tissues but it shows higher levels in the brain and kidneys indicating a potential role in the regulation of processes specific to these organs.
Biological function summary
METTL8 participates in the regulation of RNA stability and processing. It operates as part of a complex that modulates RNA modifications which can affect gene expression patterns. The methylation activity of METTL8 influences RNA metabolism having potential implications on the stability of transcripts and the overall efficiency of translation.
Pathways
METTL8 involvement in RNA processing pathways becomes evident. It plays a role within the RNA methylation pathway by interacting with other methyltransferases like METTL3. This interaction suggests that METTL8 might have a function in the N6-methyladenosine (m6A) methylation pathway that modifies the nucleobases within RNA molecules to regulate gene expression. The significance of these pathways involves the control of diverse cellular processes including development and response to cellular stress.
Abnormalities in METTL8 function have potential links to neurological disorders and certain cancers. In particular altered expression levels or mutations in METTL8 may contribute to neurodegenerative diseases correlating with aberrant RNA methylation patterns. Its role in cancer comes from the association with dysregulated methylation often seen in tumorigenesis. METTL3 a related protein also connects to these diseases highlighting the importance of the methylation network in maintaining cellular homeostasis and its disruption in disease states.