Abcam, ab122320, Anti-ANKRD23 antibody

Size: 100µL
Rabbit Polyclonal ANKRD23 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ANKRD23 aa 50-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ANKRD23 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.Q86SG2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ANKRD23 also known as Ankyrin Repeat Domain-containing protein 23 is a protein that plays a significant role in cellular processes through mechanical interactions. It weighs approximately 34 kDa. ANKRD23 is expressed in various tissues with a notable presence in the brain suggesting its involvement in neurological functions. This target belongs to the ankyrin repeat protein family recognized for specific protein-protein interactions that aid in maintaining cellular structure and signaling.
Biological function summary
ANKRD23 acts as an adaptor protein facilitating interactions between other proteins and influencing signaling pathways. It is known to be part of protein complexes involved in the regulation of cell cycle and apoptotic processes. Through these functions ANKRD23 supports cellular homeostasis and response mechanisms highlighting its importance in maintaining cellular integrity under different physiological conditions.
Pathways
ANKRD23 is associated with the Wnt signaling pathway and the NF-kB signaling pathway. These pathways are important for regulating gene transcription cellular growth and immune responses. ANKRD23 interacts with proteins such as beta-catenin in the Wnt pathway and RELA in the NF-kB pathway which are instrumental in mediating cellular responses to external stimuli and internal regulatory signals.
ANKRD23 has been linked to neurodegenerative diseases and certain cancers. In the context of neurodegenerative diseases ANKRD23's interactions with proteins such as TAU may influence the progression of conditions like Alzheimer's disease. In cancer altered expression of ANKRD23 could affect the regulatory balance within cell signaling pathways potentially interacting with p53 in cell cycle control and apoptosis evasion.