Abcam, ab122386, Anti-THAP9 antibody

Size: 100µL
Rabbit Polyclonal THAP9 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human THAP9 aa 700-800.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human THAP9 aa 700-800. The exact immunogen used to generate this antibody is proprietary information.Q9H5L6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
THAP9 also known as Thanatos-associated protein 9 is an enzyme with a molecular weight of approximately 84 kDa. This protein is part of the THAP family which is known for its DNA-binding ability through a conserved zinc finger. THAP9 is expressed in various tissues with higher expression noted in the heart liver and testes. Its function includes DNA transposition suggesting a role in genetic recombination and regulation activities.
Biological function summary
THAP9 participates in the regulation of DNA elements and may act as a transposase. It functions as part of a complex with other proteins contributing to the mobility of DNA within the genome. This activity suggests a role in maintaining genomic stability where the transposition may influence gene expression patterns and potentially affect cell differentiation and development.
Pathways
The role that THAP9 plays is particularly connected to DNA repair and replication pathways. Its activity in transposing DNA aligns it with the non-homologous end-joining pathway for DNA repair. Related proteins in these pathways include Ku70/80 and DNA-PK which THAP9 may interact with to facilitate its functions in genome maintenance and stability.
THAP9 has shown significance in genetic instability-related conditions such as cancer. The protein's role in DNA transposition may influence oncogene activation or tumor suppressor gene inactivation. Additionally it has connections to neuropsychiatric disorders possibly through its interaction with proteins like FUS linking its activity to chromosomal rearrangement and neuronal function alterations.