Abcam, ab122393, Anti-FAM190B antibody

Size: 100µL
Rabbit Polyclonal FAM190B antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Rat, Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CCSER2 aa 550-700.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CCSER2 aa 550-700. The exact immunogen used to generate this antibody is proprietary information.Q9H7U1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FAM190B also known as Family with Sequence Similarity 190 Member B is a protein encoded by the FAM190B gene. This protein has an approximate molecular weight of 114 kDa. The protein is strongly expressed in certain tissues including the brain and reproductive organs. FAM190B localizes mainly in the cytoplasm of cells where it may play roles in cell structure and signaling.
Biological function summary
FAM190B influences cellular and physiological processes. It participates in cell division and chromosomal segregation implying its involvement in maintaining genomic stability. Current evidence suggests that FAM190B does not function alone; it interacts with other proteins potentially forming part of larger cellular complexes. These interactions remain a subject of ongoing research to fully understand the protein's role in cellular dynamics.
Pathways
FAM190B contributes to critical cellular signaling networks. Specifically it is involved in the mitotic checkpoint and cell cycle regulation pathways. These pathways help control proper cell division and replication ensuring genetic information passes accurately to daughter cells. FAM190B likely interacts with other proteins such as Aurora kinases which are key regulators of mitosis and is important in the coordination of the mitotic process.
FAM190B alterations have been linked to certain types of cancer such as brain tumors and ovarian cancer. Changes in the expression or function of FAM190B may disrupt normal cell division leading to uncontrolled cell proliferation a characteristic of tumorigenesis. Studies also explore potential interactions between FAM190B and other cancer-related proteins such as p53 which is known to play an important role in suppressing tumor development and maintaining genomic integrity. Understanding these links offers insights into potential therapeutic targets for managing these malignancies.