Abcam, ab122411, Anti-MBLAC2 antibody

Size: 100µL
Rabbit Polyclonal MBLAC2 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MBLAC2 aa 100-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MBLAC2 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.Q68D91

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MBLAC2 also known as Metallo-beta-lactamase domain-containing protein 2 belongs to the metalloproteinase family. This protein has a molecular mass of around 26 kDa. MBLAC2 is expressed in various tissues including the liver and kidney. Its mechanistic role involves the hydrolysis of certain substrates through the action of its metal-ion-dependent enzymatic domain.
Biological function summary
MBLAC2 participates in cellular processes that require metalloprotease activity. Although not extensively characterized MBLAC2 contributes to the turnover of nucleic acids or proteins given its enzymatic capabilities. MBLAC2's role as a standalone protein suggests it does not form part of significant heteromeric protein complexes but it might still interact transiently with other cellular components involved in RNA or protein metabolism.
Pathways
MBLAC2 interacts mainly within pathways that involve RNA regulation and degradation. It has potential connections to RNA salvage pathways and may interact with proteins like Dicer known to participate in RNA processing. This relation suggests a link to gene expression regulation by influencing the availability of RNA substrates.
MBLAC2 exhibits associations with specific conditions such as certain cancers and neurodegenerative disorders. Its involvement in cancer could relate to its role in RNA metabolism potentially influencing tumorigenesis. Connections to proteins like BRCA1 in cancer pathways might highlight its relevance to DNA repair and genomic stability therefore linking its malfunction to disease progression.