Abcam, ab122420, Anti-STOX1 antibody

Size: 100µL
Rabbit Polyclonal STOX1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human STOX1 aa 400-550.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human STOX1 aa 400-550. The exact immunogen used to generate this antibody is proprietary information.Q6ZVD7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
STOX1 also known as Storkhead box protein 1 is a transcription factor with a molecular weight of approximately 53 kDa. It contains a DNA-binding domain similar to other forkhead box (FOX) family proteins. STOX1 is mainly expressed in tissues such as the placenta and antecubital skin and has a role in gene regulation through its DNA-binding capability. STOX1 helps modulate the expression of genes related to cell growth and differentiation.
Biological function summary
STOX1 functions as a regulator of oxidative stress responses and is involved in the transcriptional control of several critical genes. It does not operate as part of a larger complex but interacts directly with specific DNA sequences to exert its effects. By binding to target DNA sites STOX1 influences various biological processes including those related to homeostasis and cellular response to environmental stressors.
Pathways
STOX1 has a significant role in oxidative stress response and trophoblast differentiation pathways. It interacts with proteins such as HIF1A a factor integral to the cellular response to hypoxia demonstrating its involvement in managing oxidative stress. The pathways involving STOX1 contribute to maintaining a balance between cell survival and programmed cell death helping cells adapt to changing oxygen levels and other stresses.
STOX1 shows associations with preeclampsia and oxidative stress-related conditions. Preeclampsia a pregnancy complication characterized by high blood pressure has connections to STOX1 through its transcriptional regulation roles. During preeclampsia STOX1's expression is altered contributing to the pathophysiology of this disorder. Additionally the interaction with oxidative stress pathways ties STOX1 to conditions like chronic inflammation where it cooperates with proteins such as NRF2 an important regulator of antioxidant response.