Abcam, ab122449, Anti-Epiphycan antibody

Size: 100µL
Rabbit Polyclonal Epiphycan antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human EPYC aa 150-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human EPYC aa 150-300. The exact immunogen used to generate this antibody is proprietary information.Q99645

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Epiphycan also known as DSPG3 is a small leucine-rich proteoglycan with an approximate mass of 38 kDa. Epiphycan appears mainly in cartilage and the eye. It functions mechanically by interacting with collagen fibers and other components in the extracellular matrix. This interaction helps in regulating collagen fibril assembly and spacing important for maintaining tissue integrity and function.
Biological function summary
The protein plays a part in maintaining the structural integrity and resilience of connective tissues. Although Epiphycan is not part of a larger complex it works closely with other extracellular matrix molecules contributing to tissue elasticity and hydration. This role is significant in tissues such as cartilage where mechanical stress is persistent and its efficient functionality is necessary.
Pathways
This protein takes part in the assembly and organization of the extracellular matrix. It participates significantly in the collagen fibril organization pathway. This pathway involves interactions with proteins such as decorin and biglycan which are also part of the small leucine-rich proteoglycan family. These interactions are essential for maintaining the ordered arrangement of collagen fibrils in connective tissues.
Mutations or dysregulation of Epiphycan relate to skeletal dysplasias and osteoarthritis. In osteoarthritis the altered interactions within the extracellular matrix contribute to cartilage degradation and joint dysfunction. The protein's connection with decorin becomes relevant here as both engage in maintaining matrix homeostasis. Understanding these interactions helps reveal potential therapeutic targets to address these conditions.